Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain

Rhodopsin is a prototypical G protein-coupled receptor (GPCR) critical for vertebrate vision. Research on GPCR signaling states has been facilitated using llama-derived nanobodies (Nbs), some of which bind to the intracellular surface to allosterically modulate the receptor. Extracellularly binding...

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Detalles Bibliográficos
Autores principales: Wu, Arum, Salom, David, Hong, John D., Tworak, Aleksander, Watanabe, Kohei, Pardon, Els, Steyaert, Jan, Kandori, Hideki, Katayama, Kota, Kiser, Philip D., Palczewski, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457330/
https://www.ncbi.nlm.nih.gov/pubmed/37626045
http://dx.doi.org/10.1038/s41467-023-40911-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457330/
https://www.ncbi.nlm.nih.gov/pubmed/37626045
http://dx.doi.org/10.1038/s41467-023-40911-9

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