Cargando…

Suppressed Akt/GSK-3β/β-catenin signaling contributes to excessive adipogenesis of fibro-adipogenic progenitors after rotator cuff tears

Muscular fatty infiltration is a common and troublesome pathology after rotator cuff tears (RCT), which mainly derives from fibro-adipogenic progenitors (FAPs). Compared to the RCT, fatty infiltration is not so severe in Achilles tendon tears (ATT). The knowledge of why fatty infiltration is more li...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Xingzuan, Wang, Peng, Wang, Wei, Zhou, Hao, Zhu, Siyuan, Feng, Shujing, Chen, Yuzhou, Zhou, Han, Wang, Qichao, Xin, Hanlong, Shao, Xiexiang, Wang, Jianhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457376/ https://www.ncbi.nlm.nih.gov/pubmed/37626040 http://dx.doi.org/10.1038/s41420-023-01618-4

Ejemplares similares

Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis
por: Marinkovic, Milica, et al.
Publicado: (2019)

Polarized macrophages regulate fibro/adipogenic progenitor (FAP) adipogenesis through exosomes
por: Liu, Mengyao, et al.
Publicado: (2023)

IL-1β- and IL-4-polarized macrophages have opposite effects on adipogenesis of intramuscular fibro-adipogenic progenitors in humans
por: Moratal, C., et al.
Publicado: (2018)

A 3D adipogenesis platform to study the fate of fibro/adipogenic progenitors in muscular dystrophies
por: Reggio, Alessio, et al.
Publicado: (2023)

Characterization of the Skeletal Muscle Secretome Reveals a Role for Extracellular Vesicles and IL1α/IL1β in Restricting Fibro/Adipogenic Progenitor Adipogenesis
por: Vumbaca, Simone, et al.
Publicado: (2021)

TGF-β Small Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis
por: Davies, Michael R., et al.
Publicado: (2016)

The immunosuppressant drug azathioprine restrains adipogenesis of muscle Fibro/Adipogenic Progenitors from dystrophic mice by affecting AKT signaling
por: Reggio, Alessio, et al.
Publicado: (2019)

ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers
por: Gonzalez, David, et al.
Publicado: (2017)

Interleukin-15 facilitates muscle regeneration through modulation of fibro/adipogenic progenitors
por: Kang, Xia, et al.
Publicado: (2018)

Role of Metabolic Stress and Exercise in Regulating Fibro/Adipogenic Progenitors
por: Collao, Nicolas, et al.
Publicado: (2020)

Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regeneration
por: Reggio, Alessio, et al.
Publicado: (2020)

Janus effect of glucocorticoids on differentiation of muscle fibro/adipogenic progenitors
por: Cerquone Perpetuini, Andrea, et al.
Publicado: (2020)

Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases
por: Molina, Thomas, et al.
Publicado: (2021)

Diverse effector and regulatory functions of fibro/adipogenic progenitors during skeletal muscle fibrosis in muscular dystrophy
por: Wang, Xingyu, et al.
Publicado: (2022)

Retinoic acid signalling in fibro/adipogenic progenitors robustly enhances muscle regeneration
por: Zhao, Liang, et al.
Publicado: (2020)

MME(+) fibro-adipogenic progenitors are the dominant adipogenic population during fatty infiltration in human skeletal muscle
por: Fitzgerald, Gillian, et al.
Publicado: (2023)

Fibro–Adipogenic Progenitors Cross-Talk in Skeletal Muscle: The Social Network
por: Biferali, Beatrice, et al.
Publicado: (2019)

Matrix stiffness and architecture drive fibro-adipogenic progenitors’ activation into myofibroblasts
por: Loomis, Taryn, et al.
Publicado: (2022)

Determinants of epigenetic resistance to HDAC inhibitors in dystrophic fibro‐adipogenic progenitors
por: Consalvi, Silvia, et al.
Publicado: (2022)

Denervation Drives YAP/TAZ Activation in Muscular Fibro/Adipogenic Progenitors
por: Gallardo, Felipe S., et al.
Publicado: (2023)

Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva
por: Lees-Shepard, John B., et al.
Publicado: (2018)

Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophy
por: Malecova, Barbora, et al.
Publicado: (2018)

SUN-099 Fibro-adipogenic Remodeling Of The Diaphragm In Obesity-associated Respiratory Dysfunction
por: Buras, Eric, et al.
Publicado: (2019)

Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors
por: Saito, Yuki, et al.
Publicado: (2020)

SCA-1 micro-heterogeneity in the fate decision of dystrophic fibro/adipogenic progenitors
por: Giuliani, Giulio, et al.
Publicado: (2021)

Senescent fibro-adipogenic progenitors are potential drivers of pathology in inclusion body myositis
por: Nelke, Christopher, et al.
Publicado: (2023)

Fluorescence-activated cell sorting and phenotypic characterization of human fibro-adipogenic progenitors
por: Billeskov, Tine Borum, et al.
Publicado: (2023)

Mechanical Stress Regulates Osteogenesis and Adipogenesis of Rat Mesenchymal Stem Cells through PI3K/Akt/GSK-3β/β-Catenin Signaling Pathway
por: Song, Fanglong, et al.
Publicado: (2017)

Characterization of adipocytes derived from fibro/adipogenic progenitors resident in human skeletal muscle
por: Arrighi, N, et al.
Publicado: (2015)

Muscle-derived fibro-adipogenic progenitor cells for production of cultured bovine adipose tissue
por: Dohmen, Richard G. J., et al.
Publicado: (2022)

Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors—time for new definitions
por: Contreras, Osvaldo, et al.
Publicado: (2021)

Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors
por: Kotsaris, Georgios, et al.
Publicado: (2023)

Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules
por: Moseti, Dorothy, et al.
Publicado: (2016)

Reduction of senescent fibro‐adipogenic progenitors in progeria‐aged muscle by senolytics rescues the function of muscle stem cells
por: Liu, Lei, et al.
Publicado: (2022)

Increased Fibro-Adipogenic Progenitors and Intramyocellular Lipid Accumulation in Obesity-Related Skeletal Muscle Dysfunction
por: Jia, Guanghong, et al.
Publicado: (2019)

Evolving Roles of Muscle-Resident Fibro-Adipogenic Progenitors in Health, Regeneration, Neuromuscular Disorders, and Aging
por: Theret, Marine, et al.
Publicado: (2021)

Adherent muscle connective tissue fibroblasts are phenotypically and biochemically equivalent to stromal fibro/adipogenic progenitors
por: Contreras, Osvaldo, et al.
Publicado: (2019)

Muscle fibro-adipogenic progenitors from a single-cell perspective: Focus on their “virtual” secretome
por: Negroni, Elisa, et al.
Publicado: (2022)

Single-cell transcriptomic analysis of the identity and function of fibro/adipogenic progenitors in healthy and dystrophic muscle
por: Uapinyoying, Prech, et al.
Publicado: (2023)

Interleukin 4 improved adipose-derived stem cells engraftment via interacting with fibro/adipogenic progenitors in dystrophic mice
por: Li, Huan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tgrfmbf3k6b18phops7l3f35i2