PDI augments kainic acid-induced seizure activity and neuronal death by inhibiting PP2A-GluA2-PICK1-mediated AMPA receptor internalization in the mouse hippocampus

Protein disulfide isomerase (PDI) is a redox-active enzyme and also serves as a nitric oxide donor causing S-nitrosylation of cysteine residues in various proteins. Although PDI knockdown reduces α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR)-mediated neuronal activity, the un...

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Detalles Bibliográficos
Autores principales: Lee, Duk-Shin, Kim, Tae-Hyun, Park, Hana, Kim, Ji-Eun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457386/
https://www.ncbi.nlm.nih.gov/pubmed/37626185
http://dx.doi.org/10.1038/s41598-023-41014-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457386/
https://www.ncbi.nlm.nih.gov/pubmed/37626185
http://dx.doi.org/10.1038/s41598-023-41014-7

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