Glycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans

Metabolic stress caused by excess nutrients accelerates aging. We recently demonstrated that the newly discovered enzyme glycerol-3-phosphate phosphatase (G3PP; gene Pgp), which operates an evolutionarily conserved glycerol shunt that hydrolyzes glucose-derived glycerol-3-phosphate to glycerol, coun...

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Detalles Bibliográficos
Autores principales: Possik, Elite, Klein, Laura-Lee, Sanjab, Perla, Zhu, Ruyuan, Côté, Laurence, Bai, Ying, Zhang, Dongwei, Sun, Howard, Al-Mass, Anfal, Oppong, Abel, Ahmad, Rasheed, Parker, Alex, Madiraju, S.R. Murthy, Al-Mulla, Fahd, Prentki, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457390/
https://www.ncbi.nlm.nih.gov/pubmed/37626039
http://dx.doi.org/10.1038/s41467-023-40857-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457390/
https://www.ncbi.nlm.nih.gov/pubmed/37626039
http://dx.doi.org/10.1038/s41467-023-40857-y

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