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Identification of the glycosylphosphatidylinositol-specific phospholipase A2 (GPI-PLA2) that mediates GPI fatty acid remodeling in Trypanosoma brucei

The biosynthesis of glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) in the parasitic protozoan Trypanosoma brucei involves fatty acid remodeling of the GPI precursor molecules before they are transferred to protein in the endoplasmic reticulum. The genes encoding the requisite phospho...

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Detalles Bibliográficos
Autores principales: Ji, Zhe, Nagar, Rupa, Duncan, Samuel M., Sampaio Guther, Maria Lucia, Ferguson, Michael A.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457582/
https://www.ncbi.nlm.nih.gov/pubmed/37414151
http://dx.doi.org/10.1016/j.jbc.2023.105016