Mitochondrial double-stranded RNA triggers induction of the antiviral DNA deaminase APOBEC3A and nuclear DNA damage

APOBEC3A is an antiviral DNA deaminase often induced by virus infection. APOBEC3A is also a source of cancer mutation in viral and nonviral tumor types. It is therefore critical to identify factors responsible for APOBEC3A upregulation. Here, we test the hypothesis that leaked mitochondrial (mt) dou...

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Detalles Bibliográficos
Autores principales: Wick, Chloe, Moghadasi, Seyed Arad, Becker, Jordan T., Fanunza, Elisa, Oh, Sunwoo, Bournique, Elodie, Buisson, Rémi, Harris, Reuben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457583/
https://www.ncbi.nlm.nih.gov/pubmed/37474103
http://dx.doi.org/10.1016/j.jbc.2023.105073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457583/
https://www.ncbi.nlm.nih.gov/pubmed/37474103
http://dx.doi.org/10.1016/j.jbc.2023.105073

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