Isolation of mutant alleles of the U6 snRNA m (6) A methyltransferase Mtl16 and characterization of their genetic interactions with splicing mutants in Schizosaccharomyces pombe

Schizosaccharomyces pombe Dim1 is a conserved essential component of the U4/U6.U5 tri-snRNP complex essential for pre-mRNA splicing. In a synthetic lethal screen with the temperature-sensitive dim1-35 mutant, we isolated multiple alleles of non-essential mtl16 that encodes the U6 snRNA m (6) A methy...

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Detalles Bibliográficos
Autores principales: Willet, Alaina H., Ren, Liping, Turner, Lesley A., Gould, Kathleen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
Findings Previously Not Shown
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457676/
https://www.ncbi.nlm.nih.gov/pubmed/37637271
http://dx.doi.org/10.17912/micropub.biology.000948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457676/
https://www.ncbi.nlm.nih.gov/pubmed/37637271
http://dx.doi.org/10.17912/micropub.biology.000948

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