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Isolation of mutant alleles of the U6 snRNA m (6) A methyltransferase Mtl16 and characterization of their genetic interactions with splicing mutants in Schizosaccharomyces pombe

Schizosaccharomyces pombe Dim1 is a conserved essential component of the U4/U6.U5 tri-snRNP complex essential for pre-mRNA splicing. In a synthetic lethal screen with the temperature-sensitive dim1-35 mutant, we isolated multiple alleles of non-essential mtl16 that encodes the U6 snRNA m (6) A methy...

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Detalles Bibliográficos
Autores principales:	Willet, Alaina H., Ren, Liping, Turner, Lesley A., Gould, Kathleen L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Caltech Library 2023
Materias:	Findings Previously Not Shown
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457676/ https://www.ncbi.nlm.nih.gov/pubmed/37637271 http://dx.doi.org/10.17912/micropub.biology.000948

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