Cargando…
Intranasal Nanotransferosomal Gel for Quercetin Brain Targeting: II. Antidepressant Effect in an Experimental Animal Model
Depression is a serious mental disorder and the most prevalent cause of disability and suicide worldwide. Quercetin (QER) demonstrated antidepressant effects in rats exhibiting anxiety and depressive-like behaviors. In an attempt to improve QER’s antidepressant activity, a QER-loaded transferosome (...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457845/ https://www.ncbi.nlm.nih.gov/pubmed/37631309 http://dx.doi.org/10.3390/pharmaceutics15082095 |
_version_ | 1785097022423957504 |
---|---|
author | Elkomy, Mohammed H. Abo El-Ela, Fatma I. Zaki, Randa Mohammed Alsaidan, Omar A. Elmowafy, Mohammed Zafar, Ameeduzzafar Shalaby, Khaled Abdelgawad, Mohamed A. Omar, Hany A. Salama, Rania Eid, Hussein M. |
author_facet | Elkomy, Mohammed H. Abo El-Ela, Fatma I. Zaki, Randa Mohammed Alsaidan, Omar A. Elmowafy, Mohammed Zafar, Ameeduzzafar Shalaby, Khaled Abdelgawad, Mohamed A. Omar, Hany A. Salama, Rania Eid, Hussein M. |
author_sort | Elkomy, Mohammed H. |
collection | PubMed |
description | Depression is a serious mental disorder and the most prevalent cause of disability and suicide worldwide. Quercetin (QER) demonstrated antidepressant effects in rats exhibiting anxiety and depressive-like behaviors. In an attempt to improve QER’s antidepressant activity, a QER-loaded transferosome (QER-TFS) thermosensitive gel for intranasal administration was formulated and optimized. The therapeutic effectiveness of the optimized formulation was assessed in a depressed rat model by conducting a behavioral analysis. Behavioral study criteria such as immobility, swimming, climbing, sucrose intake, number of crossed lines, rearing, active interaction, and latency to feed were all considerably enhanced by intranasal treatment with the QER-TFS in situ gel in contrast to other formulations. A nasal histopathological study indicated that the QER-TFS thermosensitive gel was safe for the nasal mucosa. An immunohistochemical analysis showed that the animals treated with the QER-TFS thermosensitive gel had the lowest levels of c-fos protein expression, and brain histopathological changes in the depressed rats were alleviated. According to pharmacodynamic, immunohistochemical, and histopathological experiments, the intranasal administration of the QER-TFS thermosensitive gel substantially alleviated depressive symptoms in rats. However, extensive preclinical investigations in higher animal models are needed to anticipate its effectiveness in humans. |
format | Online Article Text |
id | pubmed-10457845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104578452023-08-27 Intranasal Nanotransferosomal Gel for Quercetin Brain Targeting: II. Antidepressant Effect in an Experimental Animal Model Elkomy, Mohammed H. Abo El-Ela, Fatma I. Zaki, Randa Mohammed Alsaidan, Omar A. Elmowafy, Mohammed Zafar, Ameeduzzafar Shalaby, Khaled Abdelgawad, Mohamed A. Omar, Hany A. Salama, Rania Eid, Hussein M. Pharmaceutics Article Depression is a serious mental disorder and the most prevalent cause of disability and suicide worldwide. Quercetin (QER) demonstrated antidepressant effects in rats exhibiting anxiety and depressive-like behaviors. In an attempt to improve QER’s antidepressant activity, a QER-loaded transferosome (QER-TFS) thermosensitive gel for intranasal administration was formulated and optimized. The therapeutic effectiveness of the optimized formulation was assessed in a depressed rat model by conducting a behavioral analysis. Behavioral study criteria such as immobility, swimming, climbing, sucrose intake, number of crossed lines, rearing, active interaction, and latency to feed were all considerably enhanced by intranasal treatment with the QER-TFS in situ gel in contrast to other formulations. A nasal histopathological study indicated that the QER-TFS thermosensitive gel was safe for the nasal mucosa. An immunohistochemical analysis showed that the animals treated with the QER-TFS thermosensitive gel had the lowest levels of c-fos protein expression, and brain histopathological changes in the depressed rats were alleviated. According to pharmacodynamic, immunohistochemical, and histopathological experiments, the intranasal administration of the QER-TFS thermosensitive gel substantially alleviated depressive symptoms in rats. However, extensive preclinical investigations in higher animal models are needed to anticipate its effectiveness in humans. MDPI 2023-08-07 /pmc/articles/PMC10457845/ /pubmed/37631309 http://dx.doi.org/10.3390/pharmaceutics15082095 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Elkomy, Mohammed H. Abo El-Ela, Fatma I. Zaki, Randa Mohammed Alsaidan, Omar A. Elmowafy, Mohammed Zafar, Ameeduzzafar Shalaby, Khaled Abdelgawad, Mohamed A. Omar, Hany A. Salama, Rania Eid, Hussein M. Intranasal Nanotransferosomal Gel for Quercetin Brain Targeting: II. Antidepressant Effect in an Experimental Animal Model |
title | Intranasal Nanotransferosomal Gel for Quercetin Brain Targeting: II. Antidepressant Effect in an Experimental Animal Model |
title_full | Intranasal Nanotransferosomal Gel for Quercetin Brain Targeting: II. Antidepressant Effect in an Experimental Animal Model |
title_fullStr | Intranasal Nanotransferosomal Gel for Quercetin Brain Targeting: II. Antidepressant Effect in an Experimental Animal Model |
title_full_unstemmed | Intranasal Nanotransferosomal Gel for Quercetin Brain Targeting: II. Antidepressant Effect in an Experimental Animal Model |
title_short | Intranasal Nanotransferosomal Gel for Quercetin Brain Targeting: II. Antidepressant Effect in an Experimental Animal Model |
title_sort | intranasal nanotransferosomal gel for quercetin brain targeting: ii. antidepressant effect in an experimental animal model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457845/ https://www.ncbi.nlm.nih.gov/pubmed/37631309 http://dx.doi.org/10.3390/pharmaceutics15082095 |
work_keys_str_mv | AT elkomymohammedh intranasalnanotransferosomalgelforquercetinbraintargetingiiantidepressanteffectinanexperimentalanimalmodel AT aboelelafatmai intranasalnanotransferosomalgelforquercetinbraintargetingiiantidepressanteffectinanexperimentalanimalmodel AT zakirandamohammed intranasalnanotransferosomalgelforquercetinbraintargetingiiantidepressanteffectinanexperimentalanimalmodel AT alsaidanomara intranasalnanotransferosomalgelforquercetinbraintargetingiiantidepressanteffectinanexperimentalanimalmodel AT elmowafymohammed intranasalnanotransferosomalgelforquercetinbraintargetingiiantidepressanteffectinanexperimentalanimalmodel AT zafarameeduzzafar intranasalnanotransferosomalgelforquercetinbraintargetingiiantidepressanteffectinanexperimentalanimalmodel AT shalabykhaled intranasalnanotransferosomalgelforquercetinbraintargetingiiantidepressanteffectinanexperimentalanimalmodel AT abdelgawadmohameda intranasalnanotransferosomalgelforquercetinbraintargetingiiantidepressanteffectinanexperimentalanimalmodel AT omarhanya intranasalnanotransferosomalgelforquercetinbraintargetingiiantidepressanteffectinanexperimentalanimalmodel AT salamarania intranasalnanotransferosomalgelforquercetinbraintargetingiiantidepressanteffectinanexperimentalanimalmodel AT eidhusseinm intranasalnanotransferosomalgelforquercetinbraintargetingiiantidepressanteffectinanexperimentalanimalmodel |