Reports of Symptoms Associated with Supraventricular Arrhythmias as a Serious Adverse Drug Reaction in the Spanish Pharmacovigilance Database
This study aimed to determine the type of drugs reported as suspected of causing severe supraventricular arrhythmias from the Spanish Human Pharmacovigilance System database. A total of 1053 reports were analysed, of which 526 (50%) were on men and 516 (49%) were on women. The most affected age grou...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457936/ https://www.ncbi.nlm.nih.gov/pubmed/37631076 http://dx.doi.org/10.3390/ph16081161 |
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author | Pueyo-Val, Javier Avedillo-Salas, Ana Berdún-Viñegra, Pablo Pueyo-Val, Olga María Fanlo-Villacampa, Ana Navarro-Pemán, Cristina Lanuza-Giménez, Francisco Javier Ioakeim-Skoufa, Ignatios Vicente-Romero, Jorge |
author_facet | Pueyo-Val, Javier Avedillo-Salas, Ana Berdún-Viñegra, Pablo Pueyo-Val, Olga María Fanlo-Villacampa, Ana Navarro-Pemán, Cristina Lanuza-Giménez, Francisco Javier Ioakeim-Skoufa, Ignatios Vicente-Romero, Jorge |
author_sort | Pueyo-Val, Javier |
collection | PubMed |
description | This study aimed to determine the type of drugs reported as suspected of causing severe supraventricular arrhythmias from the Spanish Human Pharmacovigilance System database. A total of 1053 reports were analysed, of which 526 (50%) were on men and 516 (49%) were on women. The most affected age group was the over-65s, with 593 reports (56%). Of the 1613 drugs, those belonging to the cardiovascular system (ATC Group C) were the most numerous (414 reports, 26%), with digoxin being the most frequent drug (49 reports, 12%). Other common groups were antiinfectives for systemic use (ATC Group J; 306 reports, 19%), antineoplastic and immunomodulating agents (ATC Group L; 198 reports, 12%), and nervous system drugs (ATC Group N; 185 reports, 11%). The most common supraventricular arrhythmia was atrial fibrillation (561 reports, 51%). Regarding outcomes, 730 (66%) patients recovered, 76 (7%) did not recover, 25 (3%) recovered but with sequelae, and 23 (2%) resulted in death. This study revealed that certain drugs have reported to be associated more frequently to supraventricular arrhythmias as serious adverse reactions, especially in the older population. Proper clinical management and effective strategies to ensure medication appropriateness should always be considered to improve patient safety when prescribing drugs. |
format | Online Article Text |
id | pubmed-10457936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104579362023-08-27 Reports of Symptoms Associated with Supraventricular Arrhythmias as a Serious Adverse Drug Reaction in the Spanish Pharmacovigilance Database Pueyo-Val, Javier Avedillo-Salas, Ana Berdún-Viñegra, Pablo Pueyo-Val, Olga María Fanlo-Villacampa, Ana Navarro-Pemán, Cristina Lanuza-Giménez, Francisco Javier Ioakeim-Skoufa, Ignatios Vicente-Romero, Jorge Pharmaceuticals (Basel) Article This study aimed to determine the type of drugs reported as suspected of causing severe supraventricular arrhythmias from the Spanish Human Pharmacovigilance System database. A total of 1053 reports were analysed, of which 526 (50%) were on men and 516 (49%) were on women. The most affected age group was the over-65s, with 593 reports (56%). Of the 1613 drugs, those belonging to the cardiovascular system (ATC Group C) were the most numerous (414 reports, 26%), with digoxin being the most frequent drug (49 reports, 12%). Other common groups were antiinfectives for systemic use (ATC Group J; 306 reports, 19%), antineoplastic and immunomodulating agents (ATC Group L; 198 reports, 12%), and nervous system drugs (ATC Group N; 185 reports, 11%). The most common supraventricular arrhythmia was atrial fibrillation (561 reports, 51%). Regarding outcomes, 730 (66%) patients recovered, 76 (7%) did not recover, 25 (3%) recovered but with sequelae, and 23 (2%) resulted in death. This study revealed that certain drugs have reported to be associated more frequently to supraventricular arrhythmias as serious adverse reactions, especially in the older population. Proper clinical management and effective strategies to ensure medication appropriateness should always be considered to improve patient safety when prescribing drugs. MDPI 2023-08-15 /pmc/articles/PMC10457936/ /pubmed/37631076 http://dx.doi.org/10.3390/ph16081161 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pueyo-Val, Javier Avedillo-Salas, Ana Berdún-Viñegra, Pablo Pueyo-Val, Olga María Fanlo-Villacampa, Ana Navarro-Pemán, Cristina Lanuza-Giménez, Francisco Javier Ioakeim-Skoufa, Ignatios Vicente-Romero, Jorge Reports of Symptoms Associated with Supraventricular Arrhythmias as a Serious Adverse Drug Reaction in the Spanish Pharmacovigilance Database |
title | Reports of Symptoms Associated with Supraventricular Arrhythmias as a Serious Adverse Drug Reaction in the Spanish Pharmacovigilance Database |
title_full | Reports of Symptoms Associated with Supraventricular Arrhythmias as a Serious Adverse Drug Reaction in the Spanish Pharmacovigilance Database |
title_fullStr | Reports of Symptoms Associated with Supraventricular Arrhythmias as a Serious Adverse Drug Reaction in the Spanish Pharmacovigilance Database |
title_full_unstemmed | Reports of Symptoms Associated with Supraventricular Arrhythmias as a Serious Adverse Drug Reaction in the Spanish Pharmacovigilance Database |
title_short | Reports of Symptoms Associated with Supraventricular Arrhythmias as a Serious Adverse Drug Reaction in the Spanish Pharmacovigilance Database |
title_sort | reports of symptoms associated with supraventricular arrhythmias as a serious adverse drug reaction in the spanish pharmacovigilance database |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457936/ https://www.ncbi.nlm.nih.gov/pubmed/37631076 http://dx.doi.org/10.3390/ph16081161 |
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