QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency

O(6)-methylguanine-DNA methyltransferase (MGMT) constitutes an important cellular mechanism for repairing potentially cytotoxic DNA damage induced by guanine O(6)-alkylating agents and can render cells highly resistant to certain cancer chemotherapeutic drugs. A wide variety of potential MGMT inacti...

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Detalles Bibliográficos
Autores principales: Sun, Guohui, Bai, Peiying, Fan, Tengjiao, Zhao, Lijiao, Zhong, Rugang, McElhinney, R. Stanley, McMurry, T. Brian H., Donnelly, Dorothy J., McCormick, Joan E., Kelly, Jane, Margison, Geoffrey P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458236/
https://www.ncbi.nlm.nih.gov/pubmed/37631385
http://dx.doi.org/10.3390/pharmaceutics15082170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458236/
https://www.ncbi.nlm.nih.gov/pubmed/37631385
http://dx.doi.org/10.3390/pharmaceutics15082170

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