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QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency
O(6)-methylguanine-DNA methyltransferase (MGMT) constitutes an important cellular mechanism for repairing potentially cytotoxic DNA damage induced by guanine O(6)-alkylating agents and can render cells highly resistant to certain cancer chemotherapeutic drugs. A wide variety of potential MGMT inacti...
Autores principales: | Sun, Guohui, Bai, Peiying, Fan, Tengjiao, Zhao, Lijiao, Zhong, Rugang, McElhinney, R. Stanley, McMurry, T. Brian H., Donnelly, Dorothy J., McCormick, Joan E., Kelly, Jane, Margison, Geoffrey P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458236/ https://www.ncbi.nlm.nih.gov/pubmed/37631385 http://dx.doi.org/10.3390/pharmaceutics15082170 |
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