Structure–Activity Relationship Studies on 6-Chloro-1-phenylbenzazepines Leads to the Identification of a New Dopamine D1 Receptor Antagonist

The 1-phenylbenzazepine template has yielded a number of D1R-like ligands, which, though useful as pharmacological tools, have significant drawbacks in terms of selectivity versus D5R as well as pharmacokinetic behavior. A number of 1-phenylbenzazepines contain a 6-chloro functional group, but exten...

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Detalles Bibliográficos
Autores principales: Giri, Rajan, Namballa, Hari K., Emogaje, Vishwashiv, Harding, Wayne W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458514/
https://www.ncbi.nlm.nih.gov/pubmed/37630262
http://dx.doi.org/10.3390/molecules28166010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458514/
https://www.ncbi.nlm.nih.gov/pubmed/37630262
http://dx.doi.org/10.3390/molecules28166010

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