Cu(ATSM) Increases P-Glycoprotein Expression and Function at the Blood-Brain Barrier in C57BL6/J Mice

P-glycoprotein (P-gp), expressed at the blood-brain barrier (BBB), is critical in preventing brain access to substrate drugs and effluxing amyloid beta (Aβ), a contributor to Alzheimer’s disease (AD). Strategies to regulate P-gp expression therefore may impact central nervous system (CNS) drug deliv...

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Detalles Bibliográficos
Autores principales: Pyun, Jae, Koay, HuiJing, Runwal, Pranav, Mawal, Celeste, Bush, Ashley I., Pan, Yijun, Donnelly, Paul S., Short, Jennifer L., Nicolazzo, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458578/
https://www.ncbi.nlm.nih.gov/pubmed/37631298
http://dx.doi.org/10.3390/pharmaceutics15082084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458578/
https://www.ncbi.nlm.nih.gov/pubmed/37631298
http://dx.doi.org/10.3390/pharmaceutics15082084

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