Characterization of the interferences of systemic azole antifungal drugs with adrenal steroid biosynthesis using H295R cells and enzyme activity assays

Azole antifungals, designed to inhibit fungal CYP51, have a liability to inhibit human CYP enzymes. Whilst drug-metabolizing CYPs are covered in preclinical safety assessment, those metabolizing endogenous bioactive molecules are usually not. Posaconazole and itraconazole were recently found to caus...

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Detalles Bibliográficos
Autores principales: Jäger, Marie-Christin, Joos, Friedrich L., Winter, Denise V., Odermatt, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles from the special issue on Invite 2023 edited by Thomas Knudsen
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458698/
https://www.ncbi.nlm.nih.gov/pubmed/37637492
http://dx.doi.org/10.1016/j.crtox.2023.100119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458698/
https://www.ncbi.nlm.nih.gov/pubmed/37637492
http://dx.doi.org/10.1016/j.crtox.2023.100119

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