A Rational Approach to Predicting Immediate Release Formulation Behavior in Multiple Gastric Motility Patterns: A Combination of a Biorelevant Apparatus, Design of Experiments, and Machine Learning †

Gastric mechanical stress often impacts drug dissolution from solid oral dosage forms, but in vitro experiments cannot recreate the substantial variability of gastric motility in a reasonable time. This study, for the first time, combines a novel dissolution apparatus with the design of experiments...

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Detalles Bibliográficos
Autores principales: Staniszewska, Marcela, Romański, Michał, Polak, Sebastian, Garbacz, Grzegorz, Dobosz, Justyna, Myslitska, Daria, Romanova, Svitlana, Paszkowska, Jadwiga, Danielak, Dorota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458881/
https://www.ncbi.nlm.nih.gov/pubmed/37631270
http://dx.doi.org/10.3390/pharmaceutics15082056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458881/
https://www.ncbi.nlm.nih.gov/pubmed/37631270
http://dx.doi.org/10.3390/pharmaceutics15082056

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