Translation of Monoclonal Antibodies Pharmacokinetics from Animal to Human Using Physiologically Based Modeling in Open Systems Pharmacology (OSP) Suite: A Retrospective Analysis of Bevacizumab

Interspecies translation of monoclonal antibodies (mAbs) pharmacokinetics (PK) in presence of target-mediated drug disposition (TMDD) is particularly challenging. Incorporation of TMDD in physiologically based PK (PBPK) modeling is recent and needs to be consolidated and generalized to provide bette...

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Detalles Bibliográficos
Autores principales: Pasquiers, Blaise, Benamara, Salih, Felices, Mathieu, Ternant, David, Declèves, Xavier, Puszkiel, Alicja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459442/
https://www.ncbi.nlm.nih.gov/pubmed/37631343
http://dx.doi.org/10.3390/pharmaceutics15082129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459442/
https://www.ncbi.nlm.nih.gov/pubmed/37631343
http://dx.doi.org/10.3390/pharmaceutics15082129

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