Scaffold Morphing and In Silico Design of Potential BACE-1 (β-Secretase) Inhibitors: A Hope for a Newer Dawn in Anti-Alzheimer Therapeutics

Alzheimer’s disease (AD) is the prime cause of 65–80% of dementia cases and is caused by plaque and tangle deposition in the brain neurons leading to brain cell degeneration. β-secretase (BACE-1) is a key enzyme responsible for depositing extracellular plaques made of β-amyloid protein. Therefore, e...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhatia, Shiveena, Singh, Manjinder, Sharma, Pratibha, Mujwar, Somdutt, Singh, Varinder, Mishra, Krishna Kumar, Singh, Thakur Gurjeet, Singh, Tanveer, Ahmad, Sheikh Fayaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459662/
https://www.ncbi.nlm.nih.gov/pubmed/37630283
http://dx.doi.org/10.3390/molecules28166032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459662/
https://www.ncbi.nlm.nih.gov/pubmed/37630283
http://dx.doi.org/10.3390/molecules28166032

Ejemplares similares