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Scaffold Morphing and In Silico Design of Potential BACE-1 (β-Secretase) Inhibitors: A Hope for a Newer Dawn in Anti-Alzheimer Therapeutics

Alzheimer’s disease (AD) is the prime cause of 65–80% of dementia cases and is caused by plaque and tangle deposition in the brain neurons leading to brain cell degeneration. β-secretase (BACE-1) is a key enzyme responsible for depositing extracellular plaques made of β-amyloid protein. Therefore, e...

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Detalles Bibliográficos
Autores principales:	Bhatia, Shiveena, Singh, Manjinder, Sharma, Pratibha, Mujwar, Somdutt, Singh, Varinder, Mishra, Krishna Kumar, Singh, Thakur Gurjeet, Singh, Tanveer, Ahmad, Sheikh Fayaz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459662/ https://www.ncbi.nlm.nih.gov/pubmed/37630283 http://dx.doi.org/10.3390/molecules28166032

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