Structure Activity Relationship and Molecular Docking of Some Quinazolines Bearing Sulfamerazine Moiety as New 3CLpro, cPLA2, sPLA2 Inhibitors

The current work was conducted to synthesize several novel anti-inflammatory quinazolines having sulfamerazine moieties as new 3CLpro, cPLA2, and sPLA2 inhibitors. The thioureido derivative 3 was formed when compound 2 was treated with sulfamerazine. Also, compound 3 was reacted with NH(2)-NH(2) in...

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Detalles Bibliográficos
Autores principales: Hussein, Mohammed Abdalla, Borik, Rita M., Nafie, Mohamed S., Abo-Salem, Heba M., Boshra, Sylvia A., Mohamed, Zahraa N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460087/
https://www.ncbi.nlm.nih.gov/pubmed/37630304
http://dx.doi.org/10.3390/molecules28166052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460087/
https://www.ncbi.nlm.nih.gov/pubmed/37630304
http://dx.doi.org/10.3390/molecules28166052

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