Spotlight on GOT2 in Cancer Metabolism

GOT2 is at the nexus of several critical metabolic pathways in homeostatic cellular and dysregulated cancer metabolism. Despite this, recent work has emphasized the remarkable plasticity of cancer cells to employ compensatory pathways when GOT2 is inhibited. Here, we review the metabolic roles of GO...

Descripción completa

Detalles Bibliográficos
Autores principales: Kerk, Samuel A, Garcia-Bermudez, Javier, Birsoy, Kivanc, Sherman, Mara H, Shah, Yatrik M, Lyssiotis, Costas A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460182/
https://www.ncbi.nlm.nih.gov/pubmed/37635751
http://dx.doi.org/10.2147/OTT.S382161
_version_ 1785097586995101696
author Kerk, Samuel A
Garcia-Bermudez, Javier
Birsoy, Kivanc
Sherman, Mara H
Shah, Yatrik M
Lyssiotis, Costas A
author_facet Kerk, Samuel A
Garcia-Bermudez, Javier
Birsoy, Kivanc
Sherman, Mara H
Shah, Yatrik M
Lyssiotis, Costas A
author_sort Kerk, Samuel A
collection PubMed
description GOT2 is at the nexus of several critical metabolic pathways in homeostatic cellular and dysregulated cancer metabolism. Despite this, recent work has emphasized the remarkable plasticity of cancer cells to employ compensatory pathways when GOT2 is inhibited. Here, we review the metabolic roles of GOT2, highlighting findings in both normal and cancer cells. We emphasize how cancer cells repurpose cell intrinsic metabolism and their flexibility when GOT2 is inhibited. We close by using this framework to discuss key considerations for future investigations into cancer metabolism.
format Online
Article
Text
id pubmed-10460182
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-104601822023-08-27 Spotlight on GOT2 in Cancer Metabolism Kerk, Samuel A Garcia-Bermudez, Javier Birsoy, Kivanc Sherman, Mara H Shah, Yatrik M Lyssiotis, Costas A Onco Targets Ther Review GOT2 is at the nexus of several critical metabolic pathways in homeostatic cellular and dysregulated cancer metabolism. Despite this, recent work has emphasized the remarkable plasticity of cancer cells to employ compensatory pathways when GOT2 is inhibited. Here, we review the metabolic roles of GOT2, highlighting findings in both normal and cancer cells. We emphasize how cancer cells repurpose cell intrinsic metabolism and their flexibility when GOT2 is inhibited. We close by using this framework to discuss key considerations for future investigations into cancer metabolism. Dove 2023-08-22 /pmc/articles/PMC10460182/ /pubmed/37635751 http://dx.doi.org/10.2147/OTT.S382161 Text en © 2023 Kerk et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Kerk, Samuel A
Garcia-Bermudez, Javier
Birsoy, Kivanc
Sherman, Mara H
Shah, Yatrik M
Lyssiotis, Costas A
Spotlight on GOT2 in Cancer Metabolism
title Spotlight on GOT2 in Cancer Metabolism
title_full Spotlight on GOT2 in Cancer Metabolism
title_fullStr Spotlight on GOT2 in Cancer Metabolism
title_full_unstemmed Spotlight on GOT2 in Cancer Metabolism
title_short Spotlight on GOT2 in Cancer Metabolism
title_sort spotlight on got2 in cancer metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460182/
https://www.ncbi.nlm.nih.gov/pubmed/37635751
http://dx.doi.org/10.2147/OTT.S382161
work_keys_str_mv AT kerksamuela spotlightongot2incancermetabolism
AT garciabermudezjavier spotlightongot2incancermetabolism
AT birsoykivanc spotlightongot2incancermetabolism
AT shermanmarah spotlightongot2incancermetabolism
AT shahyatrikm spotlightongot2incancermetabolism
AT lyssiotiscostasa spotlightongot2incancermetabolism

Ejemplares similares