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Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests
Unlike for advanced liver fibrosis, the practical rules for the early non-invasive diagnosis of cirrhosis in NAFLD remain not well defined. Here, we report the derivation and validation of a stepwise diagnostic algorithm in 1568 patients with NAFLD and liver biopsy coming from four independent cohor...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460420/ https://www.ncbi.nlm.nih.gov/pubmed/37633932 http://dx.doi.org/10.1038/s41467-023-40328-4 |
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author | Boursier, Jérôme Roux, Marine Costentin, Charlotte Chaigneau, Julien Fournier-Poizat, Céline Trylesinski, Aldo Canivet, Clémence M. Michalak, Sophie Le Bail, Brigitte Paradis, Valérie Bedossa, Pierre Sturm, Nathalie de Ledinghen, Victor Newsome, Philip N. |
author_facet | Boursier, Jérôme Roux, Marine Costentin, Charlotte Chaigneau, Julien Fournier-Poizat, Céline Trylesinski, Aldo Canivet, Clémence M. Michalak, Sophie Le Bail, Brigitte Paradis, Valérie Bedossa, Pierre Sturm, Nathalie de Ledinghen, Victor Newsome, Philip N. |
author_sort | Boursier, Jérôme |
collection | PubMed |
description | Unlike for advanced liver fibrosis, the practical rules for the early non-invasive diagnosis of cirrhosis in NAFLD remain not well defined. Here, we report the derivation and validation of a stepwise diagnostic algorithm in 1568 patients with NAFLD and liver biopsy coming from four independent cohorts. The study algorithm, using first the elastography-based tests Agile3+ and Agile4 and then the specialized blood tests FibroMeter(V3G) and CirrhoMeter(V3G), provides stratification in four groups, the last of which is enriched in cirrhosis (71% prevalence in the validation set). A risk prediction chart is also derived to allow estimation of the individual probability of cirrhosis. The predicted risk shows excellent calibration in the validation set, and mean difference with perfect prediction is only −2.9%. These tools improve the personalized non-invasive diagnosis of cirrhosis in NAFLD. |
format | Online Article Text |
id | pubmed-10460420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104604202023-08-28 Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests Boursier, Jérôme Roux, Marine Costentin, Charlotte Chaigneau, Julien Fournier-Poizat, Céline Trylesinski, Aldo Canivet, Clémence M. Michalak, Sophie Le Bail, Brigitte Paradis, Valérie Bedossa, Pierre Sturm, Nathalie de Ledinghen, Victor Newsome, Philip N. Nat Commun Article Unlike for advanced liver fibrosis, the practical rules for the early non-invasive diagnosis of cirrhosis in NAFLD remain not well defined. Here, we report the derivation and validation of a stepwise diagnostic algorithm in 1568 patients with NAFLD and liver biopsy coming from four independent cohorts. The study algorithm, using first the elastography-based tests Agile3+ and Agile4 and then the specialized blood tests FibroMeter(V3G) and CirrhoMeter(V3G), provides stratification in four groups, the last of which is enriched in cirrhosis (71% prevalence in the validation set). A risk prediction chart is also derived to allow estimation of the individual probability of cirrhosis. The predicted risk shows excellent calibration in the validation set, and mean difference with perfect prediction is only −2.9%. These tools improve the personalized non-invasive diagnosis of cirrhosis in NAFLD. Nature Publishing Group UK 2023-08-26 /pmc/articles/PMC10460420/ /pubmed/37633932 http://dx.doi.org/10.1038/s41467-023-40328-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Boursier, Jérôme Roux, Marine Costentin, Charlotte Chaigneau, Julien Fournier-Poizat, Céline Trylesinski, Aldo Canivet, Clémence M. Michalak, Sophie Le Bail, Brigitte Paradis, Valérie Bedossa, Pierre Sturm, Nathalie de Ledinghen, Victor Newsome, Philip N. Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests |
title | Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests |
title_full | Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests |
title_fullStr | Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests |
title_full_unstemmed | Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests |
title_short | Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests |
title_sort | practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460420/ https://www.ncbi.nlm.nih.gov/pubmed/37633932 http://dx.doi.org/10.1038/s41467-023-40328-4 |
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