Cargando…

Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests

Unlike for advanced liver fibrosis, the practical rules for the early non-invasive diagnosis of cirrhosis in NAFLD remain not well defined. Here, we report the derivation and validation of a stepwise diagnostic algorithm in 1568 patients with NAFLD and liver biopsy coming from four independent cohor...

Descripción completa

Detalles Bibliográficos
Autores principales: Boursier, Jérôme, Roux, Marine, Costentin, Charlotte, Chaigneau, Julien, Fournier-Poizat, Céline, Trylesinski, Aldo, Canivet, Clémence M., Michalak, Sophie, Le Bail, Brigitte, Paradis, Valérie, Bedossa, Pierre, Sturm, Nathalie, de Ledinghen, Victor, Newsome, Philip N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460420/
https://www.ncbi.nlm.nih.gov/pubmed/37633932
http://dx.doi.org/10.1038/s41467-023-40328-4
_version_ 1785097641269395456
author Boursier, Jérôme
Roux, Marine
Costentin, Charlotte
Chaigneau, Julien
Fournier-Poizat, Céline
Trylesinski, Aldo
Canivet, Clémence M.
Michalak, Sophie
Le Bail, Brigitte
Paradis, Valérie
Bedossa, Pierre
Sturm, Nathalie
de Ledinghen, Victor
Newsome, Philip N.
author_facet Boursier, Jérôme
Roux, Marine
Costentin, Charlotte
Chaigneau, Julien
Fournier-Poizat, Céline
Trylesinski, Aldo
Canivet, Clémence M.
Michalak, Sophie
Le Bail, Brigitte
Paradis, Valérie
Bedossa, Pierre
Sturm, Nathalie
de Ledinghen, Victor
Newsome, Philip N.
author_sort Boursier, Jérôme
collection PubMed
description Unlike for advanced liver fibrosis, the practical rules for the early non-invasive diagnosis of cirrhosis in NAFLD remain not well defined. Here, we report the derivation and validation of a stepwise diagnostic algorithm in 1568 patients with NAFLD and liver biopsy coming from four independent cohorts. The study algorithm, using first the elastography-based tests Agile3+ and Agile4 and then the specialized blood tests FibroMeter(V3G) and CirrhoMeter(V3G), provides stratification in four groups, the last of which is enriched in cirrhosis (71% prevalence in the validation set). A risk prediction chart is also derived to allow estimation of the individual probability of cirrhosis. The predicted risk shows excellent calibration in the validation set, and mean difference with perfect prediction is only −2.9%. These tools improve the personalized non-invasive diagnosis of cirrhosis in NAFLD.
format Online
Article
Text
id pubmed-10460420
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-104604202023-08-28 Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests Boursier, Jérôme Roux, Marine Costentin, Charlotte Chaigneau, Julien Fournier-Poizat, Céline Trylesinski, Aldo Canivet, Clémence M. Michalak, Sophie Le Bail, Brigitte Paradis, Valérie Bedossa, Pierre Sturm, Nathalie de Ledinghen, Victor Newsome, Philip N. Nat Commun Article Unlike for advanced liver fibrosis, the practical rules for the early non-invasive diagnosis of cirrhosis in NAFLD remain not well defined. Here, we report the derivation and validation of a stepwise diagnostic algorithm in 1568 patients with NAFLD and liver biopsy coming from four independent cohorts. The study algorithm, using first the elastography-based tests Agile3+ and Agile4 and then the specialized blood tests FibroMeter(V3G) and CirrhoMeter(V3G), provides stratification in four groups, the last of which is enriched in cirrhosis (71% prevalence in the validation set). A risk prediction chart is also derived to allow estimation of the individual probability of cirrhosis. The predicted risk shows excellent calibration in the validation set, and mean difference with perfect prediction is only −2.9%. These tools improve the personalized non-invasive diagnosis of cirrhosis in NAFLD. Nature Publishing Group UK 2023-08-26 /pmc/articles/PMC10460420/ /pubmed/37633932 http://dx.doi.org/10.1038/s41467-023-40328-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Boursier, Jérôme
Roux, Marine
Costentin, Charlotte
Chaigneau, Julien
Fournier-Poizat, Céline
Trylesinski, Aldo
Canivet, Clémence M.
Michalak, Sophie
Le Bail, Brigitte
Paradis, Valérie
Bedossa, Pierre
Sturm, Nathalie
de Ledinghen, Victor
Newsome, Philip N.
Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests
title Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests
title_full Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests
title_fullStr Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests
title_full_unstemmed Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests
title_short Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests
title_sort practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460420/
https://www.ncbi.nlm.nih.gov/pubmed/37633932
http://dx.doi.org/10.1038/s41467-023-40328-4
work_keys_str_mv AT boursierjerome practicaldiagnosisofcirrhosisinnonalcoholicfattyliverdiseaseusingcurrentlyavailablenoninvasivefibrosistests
AT rouxmarine practicaldiagnosisofcirrhosisinnonalcoholicfattyliverdiseaseusingcurrentlyavailablenoninvasivefibrosistests
AT costentincharlotte practicaldiagnosisofcirrhosisinnonalcoholicfattyliverdiseaseusingcurrentlyavailablenoninvasivefibrosistests
AT chaigneaujulien practicaldiagnosisofcirrhosisinnonalcoholicfattyliverdiseaseusingcurrentlyavailablenoninvasivefibrosistests
AT fournierpoizatceline practicaldiagnosisofcirrhosisinnonalcoholicfattyliverdiseaseusingcurrentlyavailablenoninvasivefibrosistests
AT trylesinskialdo practicaldiagnosisofcirrhosisinnonalcoholicfattyliverdiseaseusingcurrentlyavailablenoninvasivefibrosistests
AT canivetclemencem practicaldiagnosisofcirrhosisinnonalcoholicfattyliverdiseaseusingcurrentlyavailablenoninvasivefibrosistests
AT michalaksophie practicaldiagnosisofcirrhosisinnonalcoholicfattyliverdiseaseusingcurrentlyavailablenoninvasivefibrosistests
AT lebailbrigitte practicaldiagnosisofcirrhosisinnonalcoholicfattyliverdiseaseusingcurrentlyavailablenoninvasivefibrosistests
AT paradisvalerie practicaldiagnosisofcirrhosisinnonalcoholicfattyliverdiseaseusingcurrentlyavailablenoninvasivefibrosistests
AT bedossapierre practicaldiagnosisofcirrhosisinnonalcoholicfattyliverdiseaseusingcurrentlyavailablenoninvasivefibrosistests
AT sturmnathalie practicaldiagnosisofcirrhosisinnonalcoholicfattyliverdiseaseusingcurrentlyavailablenoninvasivefibrosistests
AT deledinghenvictor practicaldiagnosisofcirrhosisinnonalcoholicfattyliverdiseaseusingcurrentlyavailablenoninvasivefibrosistests
AT practicaldiagnosisofcirrhosisinnonalcoholicfattyliverdiseaseusingcurrentlyavailablenoninvasivefibrosistests
AT practicaldiagnosisofcirrhosisinnonalcoholicfattyliverdiseaseusingcurrentlyavailablenoninvasivefibrosistests
AT newsomephilipn practicaldiagnosisofcirrhosisinnonalcoholicfattyliverdiseaseusingcurrentlyavailablenoninvasivefibrosistests