A non-coding insertional mutation of Grhl2 causes gene over-expression and multiple structural anomalies including cleft palate, spina bifida and encephalocele

Orofacial clefts, including cleft lip and palate (CL/P) and neural tube defects (NTDs) are among the most common congenital anomalies, but knowledge of the genetic basis of these conditions remains incomplete. The extent to which genetic risk factors are shared between CL/P, NTDs and related anomali...

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Detalles Bibliográficos
Autores principales: Crane-Smith, Zoe, De Castro, Sandra C P, Nikolopoulou, Evanthia, Wolujewicz, Paul, Smedley, Damian, Lei, Yunping, Mather, Emma, Santos, Chloe, Hopkinson, Mark, Pitsillides, Andrew A, Finnell, Richard H, Ross, M Elisabeth, Copp, Andrew J, Greene, Nicholas D E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460492/
https://www.ncbi.nlm.nih.gov/pubmed/37364051
http://dx.doi.org/10.1093/hmg/ddad094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460492/
https://www.ncbi.nlm.nih.gov/pubmed/37364051
http://dx.doi.org/10.1093/hmg/ddad094

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