Population pharmacokinetic and pharmacokinetic-pharmacodynamic modeling of bempedoic acid and low-density lipoprotein cholesterol in healthy subjects and patients with dyslipidemia

Population pharmacokinetics (popPK) of bempedoic acid and the popPK/pharmacodynamic (popPK/PD) relationship between bempedoic acid concentrations and serum low-density lipoprotein cholesterol (LDL-C) from baseline were characterized. A two-compartment disposition model with a transit absorption comp...

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Detalles Bibliográficos
Autores principales: Jadhav, Satyawan B., Amore, Benny M., Bockbrader, Howard, Crass, Ryan L., Chapel, Sunny, Sasiela, William J., Emery, Maurice G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460718/
https://www.ncbi.nlm.nih.gov/pubmed/37243877
http://dx.doi.org/10.1007/s10928-023-09864-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460718/
https://www.ncbi.nlm.nih.gov/pubmed/37243877
http://dx.doi.org/10.1007/s10928-023-09864-w

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