Physiologically-based pharmacokinetic modeling to predict drug-drug interaction of enzalutamide with combined P-gp and CYP3A substrates

Enzalutamide is known to strongly induce cytochrome P450 3A4 (CYP3A4). Furthermore, enzalutamide showed induction and inhibition of P-glycoprotein (P-gp) in in vitro studies. A clinical drug-drug interaction (DDI) study between enzalutamide and digoxin, a typical P-gp substrate, suggested enzalutami...

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Detalles Bibliográficos
Autores principales: Otsuka, Yukio, Poondru, Srinivasu, Bonate, Peter L., Rose, Rachel H., Jamei, Masoud, Ushigome, Fumihiko, Minematsu, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460728/
https://www.ncbi.nlm.nih.gov/pubmed/37344637
http://dx.doi.org/10.1007/s10928-023-09867-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460728/
https://www.ncbi.nlm.nih.gov/pubmed/37344637
http://dx.doi.org/10.1007/s10928-023-09867-7

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