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A two-stages global sensitivity analysis by using the δ sensitivity index in presence of correlated inputs: application on a tumor growth inhibition model based on the dynamic energy budget theory

Global sensitivity analysis (GSA) evaluates the impact of variability and/or uncertainty of the model parameters on given model outputs. GSA is useful for assessing the quality of Pharmacometric model inference. Indeed, model parameters can be affected by high (estimation) uncertainty due to the spa...

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Detalles Bibliográficos
Autores principales: De Carlo, Alessandro, Tosca, Elena Maria, Melillo, Nicola, Magni, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460734/
https://www.ncbi.nlm.nih.gov/pubmed/37422844
http://dx.doi.org/10.1007/s10928-023-09872-w