A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection

Developing CD4(+)CD8(+) double-positive (DP) thymocytes with randomly generated T cell receptors (TCRs) undergo positive (maturation) or negative (apoptosis) selection on the basis of the strength of TCR stimulation. Selection fate is determined by engagement of TCR ligands with a subtle difference...

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Detalles Bibliográficos
Autores principales: Funasaki, Shintaro, Hatano, Atsushi, Nakatsumi, Hirokazu, Koga, Daisuke, Sugahara, Osamu, Yumimoto, Kanae, Baba, Masaya, Matsumoto, Masaki, Nakayama, Keiichi I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460994/
https://www.ncbi.nlm.nih.gov/pubmed/37646020
http://dx.doi.org/10.1016/j.isci.2023.107552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460994/
https://www.ncbi.nlm.nih.gov/pubmed/37646020
http://dx.doi.org/10.1016/j.isci.2023.107552

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