Cargando…
A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection
Developing CD4(+)CD8(+) double-positive (DP) thymocytes with randomly generated T cell receptors (TCRs) undergo positive (maturation) or negative (apoptosis) selection on the basis of the strength of TCR stimulation. Selection fate is determined by engagement of TCR ligands with a subtle difference...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460994/ https://www.ncbi.nlm.nih.gov/pubmed/37646020 http://dx.doi.org/10.1016/j.isci.2023.107552 |