Cargando…

Promoting the activity of a receptor tyrosine phosphatase with a novel pH‐responsive transmembrane agonist inhibits cancer‐associated phenotypes

Cell signaling by receptor protein tyrosine kinases (RTKs) is tightly controlled by the counterbalancing actions of receptor protein tyrosine phosphatases (RPTPs). Due to their role in attenuating the signal‐initiating potency of RTKs, RPTPs have long been viewed as therapeutic targets. However, the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rizzo, Sophie, Sikorski, Eden, Park, Soohyung, Im, Wonpil, Vasquez‐Montes, Victor, Ladokhin, Alexey S., Thévenin, Damien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461461/ https://www.ncbi.nlm.nih.gov/pubmed/37515426 http://dx.doi.org/10.1002/pro.4742

Ejemplares similares

Correction: Disrupting the transmembrane domain–mediated oligomerization of protein tyrosine phosphatase receptor J inhibits EGFR-driven cancer cell phenotypes
por: Bloch, Elizabeth, et al.
Publicado: (2022)

Unsaturated Lipids Facilitate Partitioning of Transmembrane Peptides into the Liquid Ordered Phase
por: Park, Soohyung, et al.
Publicado: (2023)

Disrupting PTPRJ transmembrane-mediated oligomerization counteracts oncogenic receptor tyrosine kinase FLT3 ITD
por: Schwarz, Marie, et al.
Publicado: (2022)

T cell and B cell antigen receptors share a conserved core transmembrane structure
por: Ramesh, Samyuktha, et al.
Publicado: (2022)

Theory of Adaptive Optimization for Umbrella Sampling
por: Park, Soohyung, et al.
Publicado: (2014)

pH-Triggered Conformational Switching along the Membrane Insertion Pathway of the Diphtheria Toxin T-Domain
por: Ladokhin, Alexey S.
Publicado: (2013)

Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex
Publicado: (1996)

CHARMM-GUI Membrane Builder: Past, Current, and Future Developments and Applications
por: Feng, Shasha, et al.
Publicado: (2023)

Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase
por: Mattila, Elina, et al.
Publicado: (2010)

How Tolerant are Membrane Simulations with Mismatch in Area per Lipid between Leaflets?
por: Park, Soohyung, et al.
Publicado: (2015)

CHARMM-GUI Membrane Builder for Lipid Nanoparticles with Ionizable Cationic Lipids and PEGylated Lipids
por: Park, Soohyung, et al.
Publicado: (2021)

The Laminin–Nidogen Complex is a Ligand for a Specific Splice Isoform of the Transmembrane Protein Tyrosine Phosphatase LAR
por: O'Grady, Pauline, et al.
Publicado: (1998)

Conformational Switching in Bcl-xL: Enabling Non-Canonic Inhibition of Apoptosis Involves Multiple Intermediates and Lipid Interactions
por: Vasquez-Montes, Victor, et al.
Publicado: (2020)

Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis
por: Su, Tung-Hung, et al.
Publicado: (2017)

Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases
por: Shen, Ruidan, et al.
Publicado: (2021)

Hydrogen–Deuterium Exchange and Mass Spectrometry Reveal the pH-Dependent Conformational Changes of Diphtheria Toxin T Domain
por: Li, Jing, et al.
Publicado: (2014)

Effects of Cardiolipin on the Conformational Dynamics of Membrane-Anchored Bcl-xL
por: Tyagi, Vivek, et al.
Publicado: (2021)

Importance of tyrosine phosphorylation for transmembrane signaling in plants
por: Mühlenbeck, Henning, et al.
Publicado: (2021)

pH-Selective Cytotoxicity of pHLIP-Antimicrobial Peptide Conjugates
por: Burns, Kelly E., et al.
Publicado: (2016)

The tyrosine phosphatase Ptpn22 discriminates weak, self-peptide from strong agonist T cell receptor signals
por: Salmond, Robert J., et al.
Publicado: (2014)

Structure of the Diphtheria Toxin at Acidic pH: Implications for the Conformational Switching of the Translocation Domain
por: Rodnin, Mykola V., et al.
Publicado: (2020)

Protein tyrosine phosphatases in glioma biology
por: Navis, Anna C., et al.
Publicado: (2009)

Metabolic regulation by protein tyrosine phosphatases
por: Knobler, Hilla, et al.
Publicado: (2014)

Role of Protein Tyrosine Phosphatases in Plants
por: Shankar, Alka, et al.
Publicado: (2015)

Crystal structure of the Yersinia tyrosine phosphatase
por: Bliska, James B.
Publicado: (1995)

T Cell Protein Tyrosine Phosphatase in Osteoimmunology
por: Wang, Ya-nan, et al.
Publicado: (2021)

Protein tyrosine phosphatases in cell adhesion
por: Young, Katherine A., et al.
Publicado: (2021)

Protein Tyrosine Phosphatases: Mechanisms in Cancer
por: Sivaganesh, Vignesh, et al.
Publicado: (2021)

Cellular Entry of Binary and Pore-Forming Bacterial Toxins
por: Ladokhin, Alexey S.
Publicado: (2017)

Regulation of Apoptosis by the Bcl-2 Family of Proteins: Field on a Brink
por: Ladokhin, Alexey S.
Publicado: (2020)

Ukrainian science in the context of its anticolonial struggle
por: Ladokhin, Alexey S.
Publicado: (2023)

Targeting Protein-Tyrosine Phosphatases in Breast Cancer
por: Aceto, Nicola, et al.
Publicado: (2012)

Central Regulation of Metabolism by Protein Tyrosine Phosphatases
por: Tsou, Ryan C., et al.
Publicado: (2013)

Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
por: Wakuda, Yusuke, et al.
Publicado: (2006)

Receptor-type protein tyrosine phosphatases in cancer
por: Du, Yu, et al.
Publicado: (2015)

Protein tyrosine phosphatases in cardiac physiology and pathophysiology
por: Wade, Fallou, et al.
Publicado: (2018)

The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma
por: Huang, Yide, et al.
Publicado: (2018)

Proteinaceous Regulators and Inhibitors of Protein Tyrosine Phosphatases
por: Hendriks, Wiljan, et al.
Publicado: (2018)

The Role of Protein Tyrosine Phosphatases in Inflammasome Activation
por: Spalinger, Marianne R., et al.
Publicado: (2020)

Activation of tyrosine phosphatases in the progression of Alzheimer's disease
por: Stewart, Alexandre F. R., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1qc174tb3lt2iaj2f5bg06anmb