Early chromosome condensation by XIST builds A-repeat RNA density that facilitates gene silencing

XIST RNA triggers chromosome-wide gene silencing and condenses an active chromosome into a Barr body. Here, we use inducible human XIST to examine early steps in the process, showing that XIST modifies cytoarchitecture before widespread gene silencing. In just 2–4 h, barely visible transcripts popul...

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Detalles Bibliográficos
Autores principales: Valledor, Melvys, Byron, Meg, Dumas, Brett, Carone, Dawn M., Hall, Lisa L., Lawrence, Jeanne B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461597/
https://www.ncbi.nlm.nih.gov/pubmed/37384527
http://dx.doi.org/10.1016/j.celrep.2023.112686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461597/
https://www.ncbi.nlm.nih.gov/pubmed/37384527
http://dx.doi.org/10.1016/j.celrep.2023.112686

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