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Early chromosome condensation by XIST builds A-repeat RNA density that facilitates gene silencing
XIST RNA triggers chromosome-wide gene silencing and condenses an active chromosome into a Barr body. Here, we use inducible human XIST to examine early steps in the process, showing that XIST modifies cytoarchitecture before widespread gene silencing. In just 2–4 h, barely visible transcripts popul...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461597/ https://www.ncbi.nlm.nih.gov/pubmed/37384527 http://dx.doi.org/10.1016/j.celrep.2023.112686 |