Site-specific acetylation of polynucleotide kinase 3’-phosphatase (PNKP) regulates its distinct role in DNA repair pathways

Mammalian polynucleotide kinase 3’-phosphatase (PNKP) is a dual-function DNA end-processing enzyme with 3’-phosphatase and 5’-kinase activities, which generate 3’-OH and 5’-phosphate termini respectively, as substrates for DNA polymerase and DNA ligase to complete DNA repair. PNKP is thus involved i...

Descripción completa

Detalles Bibliográficos
Autores principales: Islam, Azharul, Chakraborty, Anirban, Sarker, Altaf H, Aryal, Uma K, Sharma, Gulshan, Boldogh, Istvan, Hazra, Tapas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461918/
https://www.ncbi.nlm.nih.gov/pubmed/37645927
http://dx.doi.org/10.1101/2023.06.21.545973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461918/
https://www.ncbi.nlm.nih.gov/pubmed/37645927
http://dx.doi.org/10.1101/2023.06.21.545973

Ejemplares similares