The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis

Elevated levels of branched chain amino acids (BCAAs) and branched-chain α-ketoacids (BCKAs) are associated with cardiovascular and metabolic disease, but the molecular mechanisms underlying a putative causal relationship remain unclear. The branched-chain ketoacid dehydrogenase kinase (BCKDK) inhib...

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Detalles Bibliográficos
Autores principales: Acevedo, Aracely, Jones, Anthony E., Danna, Bezawit T., Turner, Rory, Montales, Katrina P., Benincá, Cristiane, Reue, Karen, Shirihai, Orian S., Stiles, Linsey, Wallace, Martina, Wang, Yibin, Bertholet, Ambre M., Divakaruni, Ajit S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461965/
https://www.ncbi.nlm.nih.gov/pubmed/37645724
http://dx.doi.org/10.1101/2023.08.15.553413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461965/
https://www.ncbi.nlm.nih.gov/pubmed/37645724
http://dx.doi.org/10.1101/2023.08.15.553413

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