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Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains

G protein-coupled receptors (GPCRs) control intracellular signaling cascades via agonist-dependent coupling to intracellular transducers including heterotrimeric G proteins, GPCR kinases (GRKs), and arrestins. In addition to their critical interactions with the transmembrane core of active GPCRs, al...

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Detalles Bibliográficos
Autores principales: Mancinelli, Chiara, Marx, Dagan C., Gonzalez-Hernandez, Alberto J., Mancinelli, Lucia, Khelashvilli, George, Levitz, Joshua, Eliezer, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462050/
https://www.ncbi.nlm.nih.gov/pubmed/37645938
http://dx.doi.org/10.1101/2023.08.16.553551