The α-crystallin chaperones undergo a quasi-ordered co-aggregation process in response to saturating client interaction

Small heat shock proteins (sHSPs) are ATP-independent chaperones vital to cellular proteostasis, preventing protein aggregation events linked to various human diseases including cataract. The α-crystallins, αA-crystallin (αAc) and αB-crystallin (αBc), represent archetypal sHSPs that exhibit complex...

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Detalles Bibliográficos
Autores principales: Miller, Adam P., O’Neill, Susan E., Lampi, Kirsten J., Reichow, Steve L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462102/
https://www.ncbi.nlm.nih.gov/pubmed/37645910
http://dx.doi.org/10.1101/2023.08.15.553435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462102/
https://www.ncbi.nlm.nih.gov/pubmed/37645910
http://dx.doi.org/10.1101/2023.08.15.553435

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