Double mutation of open syntaxin and UNC-18 P334A leads to excitatory-inhibitory imbalance and impairs multiple aspects of C. elegans behavior

SNARE and Sec/Munc18 proteins are essential in synaptic vesicle exocytosis. Open form t-SNARE syntaxin and UNC-18 P334A are well-studied exocytosis-enhancing mutants. Here we investigate the interrelationship between the two mutations by generating double mutants in various genetic backgrounds in C....

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Detalles Bibliográficos
Autores principales: Huang, Mengjia, Wang, Ya, Chow, Chun Hin, Stepien, Karolina P., Indrawinata, Karen, Xu, Junjie, Argiropoulos, Peter, Xie, Xiaoyu, Sugita, Kyoko, Tien, Chi-Wei, Lee, Soomin, Monnier, Philippe P., Rizo, Josep, Gao, Shangbang, Sugita, Shuzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462135/
https://www.ncbi.nlm.nih.gov/pubmed/37645974
http://dx.doi.org/10.1101/2023.08.18.553709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462135/
https://www.ncbi.nlm.nih.gov/pubmed/37645974
http://dx.doi.org/10.1101/2023.08.18.553709

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