Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors

Proteasomes are essential for protein homeostasis in mammalian cells(1–4) and in protozoan parasites such as Trichomonas vaginalis (Tv).(5) Tv and other protozoan 20S proteasomes have been validated as druggable targets.(6–8) However, in the case of Tv 20S proteasome (Tv20S), biochemical and structu...

Descripción completa

Detalles Bibliográficos
Autores principales: Silhan, Jan, Fajtova, Pavla, Bartosova, Jitka, Hurysz, Brianna M., Almaliti, Jehad, Miyamoto, Yukiko, Eckmann, Lars, Gerwick, William H., O’Donoghue, Anthony J., Boura, Evzen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462138/
https://www.ncbi.nlm.nih.gov/pubmed/37645851
http://dx.doi.org/10.1101/2023.08.17.553660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462138/
https://www.ncbi.nlm.nih.gov/pubmed/37645851
http://dx.doi.org/10.1101/2023.08.17.553660

Ejemplares similares