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Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors
Proteasomes are essential for protein homeostasis in mammalian cells(1–4) and in protozoan parasites such as Trichomonas vaginalis (Tv).(5) Tv and other protozoan 20S proteasomes have been validated as druggable targets.(6–8) However, in the case of Tv 20S proteasome (Tv20S), biochemical and structu...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462138/ https://www.ncbi.nlm.nih.gov/pubmed/37645851 http://dx.doi.org/10.1101/2023.08.17.553660 |