Acylation of MLKL impacts its function in necroptosis

Mixed lineage kinase domain-like (MLKL) is a key signaling protein of necroptosis. Upon activation by phosphorylation, MLKL translocates to the plasma membrane and induces membrane permeabilization which contributes to the necroptosis-associated inflammation. Membrane binding of MLKL is initially in...

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Detalles Bibliográficos
Autores principales: Pradhan, Apoorva J., Chitkara, Shweta, Ramirez, Ricardo X., Monje-Galvan, Viviana, Sancak, Yasemin, Ekin Atilla-Gokcumen, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462141/
https://www.ncbi.nlm.nih.gov/pubmed/37645912
http://dx.doi.org/10.1101/2023.08.19.553906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462141/
https://www.ncbi.nlm.nih.gov/pubmed/37645912
http://dx.doi.org/10.1101/2023.08.19.553906

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