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Evaluation of the RNA-dependence of PRC2 binding to chromatin in human pluripotent stem cells

Polycomb Repressive Complex 2 (PRC2), an important histone modifier and epigenetic repressor, has been known to interact with RNA for almost two decades. In our previous publication (Long, Hwang et al. 2020), we presented data supporting the functional importance of RNA interaction in maintaining PR...

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Detalles Bibliográficos
Autores principales: Long, Yicheng, Hwang, Taeyoung, Gooding, Anne R., Goodrich, Karen J., Vallery, Tenaya K., Rinn, John L., Cech, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462166/
https://www.ncbi.nlm.nih.gov/pubmed/37645830
http://dx.doi.org/10.1101/2023.08.17.553776