Polygenic Risk Score Improves Prediction of Primary Open Angle Glaucoma Onset in the Ocular Hypertension Treatment Study

OBJECTIVE OR PURPOSE: Primary open-angle glaucoma (POAG) is a highly heritable disease with 127 identified risk loci. Polygenic risks score (PRS) offers a measure of aggregate genetic burden. In this study, we assess whether PRS improves risk stratification in patients with ocular hypertension. DESI...

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Detalles Bibliográficos
Autores principales: Singh, Rishabh K., Zhao, Yan, Elze, Tobias, Fingert, John, Gordon, Mae, Kass, Michael A., Luo, Yuyang, Pasquale, Louis R., Scheetz, Todd, Segrè, Ayellet V., Wiggs, Janey L., Zebardast, Nazlee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462203/
https://www.ncbi.nlm.nih.gov/pubmed/37645858
http://dx.doi.org/10.1101/2023.08.15.23294141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462203/
https://www.ncbi.nlm.nih.gov/pubmed/37645858
http://dx.doi.org/10.1101/2023.08.15.23294141

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