Carriers of rare damaging CCR2 genetic variants are at lower risk of atherosclerotic disease

BACKGROUND: The CCL2/CCR2 axis governs monocyte trafficking and recruitment to atherosclerotic lesions. Human genetic analyses and population-based studies support an association between circulating CCL2 levels and atherosclerosis. Still, it remains unknown whether pharmacological targeting of CCR2,...

Descripción completa

Detalles Bibliográficos
Autores principales: Georgakis, Marios K., Malik, Rainer, Hasbani, Natalie R., Shakt, Gabrielle, Morrison, Alanna C., Tsao, Noah L., Judy, Renae, Mitchell, Braxton D., Xu, Huichun, Montasser, May E., Do, Ron, Kenny, Eimear E., Loos, Ruth J.F., Terry, James G., Carr, John Jeffrey, Bis, Joshua C., Psaty, Bruce M., Longstreth, W. T., Young, Kendra A, Lutz, Sharon M, Cho, Michael H, Broome, Jai, Khan, Alyna T., Wang, Fei Fei, Heard-Costa, Nancy, Seshadri, Sudha, Vasan, Ramachandran S., Palmer, Nicholette D., Freedman, Barry I., Bowden, Donald W., Yanek, Lisa R., Kral, Brian G., Becker, Lewis C., Peyser, Patricia A., Bielak, Lawrence F., Ammous, Farah, Carson, April P., Hall, Michael E., Raffield, Laura M., Rich, Stephen S., Post, Wendy S., Tracy, Russel P., Taylor, Kent D., Guo, Xiuqing, Mahaney, Michael C., Curran, Joanne E., Blangero, John, Clarke, Shoa L., Haessler, Jeffrey W., Hu, Yao, Assimes, Themistocles L., Kooperberg, Charles, Damrauer, Scott M., Rotter, Jerome I., de Vries, Paul S., Dichgans, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462211/
https://www.ncbi.nlm.nih.gov/pubmed/37645892
http://dx.doi.org/10.1101/2023.08.14.23294063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462211/
https://www.ncbi.nlm.nih.gov/pubmed/37645892
http://dx.doi.org/10.1101/2023.08.14.23294063

Ejemplares similares