Inhibiting Anti-angiogenic VEGF165b Activates a Novel miR-17-20a-Calcipressin-3 Pathway that Revascularizes Ischemic Muscle in Peripheral Artery Disease

BACKGROUND: VEGF(165)a increases the expression of microRNA-17-92 cluster, promoting developmental, retinal, and tumor angiogenesis. We have previously shown that VEGF(165)b, an alternatively spliced VEGF-A isoform, inhibits the VEGFR-STAT3 pathway in ischemic endothelial cells (ECs) to decrease the...

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Detalles Bibliográficos
Autores principales: Batan, S, Kuppuswamy, S, Wood, M, Reddy, M, Annex, BH, Ganta, VC
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462251/
https://www.ncbi.nlm.nih.gov/pubmed/37645966
http://dx.doi.org/10.21203/rs.3.rs-3213504/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462251/
https://www.ncbi.nlm.nih.gov/pubmed/37645966
http://dx.doi.org/10.21203/rs.3.rs-3213504/v1

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