Cargando…

Inhibiting Anti-angiogenic VEGF165b Activates a Novel miR-17-20a-Calcipressin-3 Pathway that Revascularizes Ischemic Muscle in Peripheral Artery Disease

BACKGROUND: VEGF(165)a increases the expression of microRNA-17-92 cluster, promoting developmental, retinal, and tumor angiogenesis. We have previously shown that VEGF(165)b, an alternatively spliced VEGF-A isoform, inhibits the VEGFR-STAT3 pathway in ischemic endothelial cells (ECs) to decrease the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Batan, S, Kuppuswamy, S, Wood, M, Reddy, M, Annex, BH, Ganta, VC
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462251/ https://www.ncbi.nlm.nih.gov/pubmed/37645966 http://dx.doi.org/10.21203/rs.3.rs-3213504/v1

Ejemplares similares

Targeting Anti-Angiogenic VEGF(165)b–VEGFR1 Signaling Promotes Nitric Oxide Independent Therapeutic Angiogenesis in Preclinical Peripheral Artery Disease Models
por: Kuppuswamy, Sivaraman, et al.
Publicado: (2022)

Systems Pharmacology of VEGF165b in Peripheral Artery Disease
por: Clegg, Lindsay E., et al.
Publicado: (2017)

A multiscale computational model predicts distribution of anti-angiogenic isoform VEGF(165b) in peripheral arterial disease in human and mouse
por: Chu, Liang-Hui, et al.
Publicado: (2016)

VEGF(121)b and VEGF(165)b are weakly angiogenic isoforms of VEGF-A
por: Catena, Raúl, et al.
Publicado: (2010)

Combined Transfer of Human VEGF165 and HGF Genes Renders Potent Angiogenic Effect in Ischemic Skeletal Muscle
por: Makarevich, Pavel, et al.
Publicado: (2012)

Angiogenic Effects of Collagen/Mesoporous Nanoparticle Composite Scaffold Delivering VEGF(165)
por: Kim, Joong-Hyun, et al.
Publicado: (2016)

The endogenous anti-angiogenic VEGF isoform, VEGF(165)b inhibits human tumour growth in mice
por: Rennel, E S, et al.
Publicado: (2008)

Transplantation of modified human adipose derived stromal cells expressing VEGF165 results in more efficient angiogenic response in ischemic skeletal muscle
por: Shevchenko, Evgeny K, et al.
Publicado: (2013)

Angiogenic and pleiotropic effects of VEGF165 and HGF combined gene therapy in a rat model of myocardial infarction
por: Makarevich, Pavel I., et al.
Publicado: (2018)

The splicing factor YBX1 promotes the progression of osteosarcoma by upregulating VEGF(165) and downregulating VEGF(165b)
por: Quan, Bingxuan, et al.
Publicado: (2023)

Dynamics and implications of circulating anti-angiogenic VEGF-A(165)b isoform in patients with ST-elevation myocardial infarction
por: Hueso, Luisa, et al.
Publicado: (2017)

Expression of Total Vascular Endothelial Growth Factor and the Anti-angiogenic VEGF(165)b Isoform in the Vitreous of Patients with Retinopathy of Prematurity
por: Zhao, Min, et al.
Publicado: (2015)

Angiogenic Modification of Microfibrous Polycaprolactone by pCMV-VEGF165 Plasmid Promotes Local Vascular Growth after Implantation in Rats
por: Klabukov, Ilya, et al.
Publicado: (2023)

The Ca(2+)/Calcineurin-Dependent Signaling Pathway in the Gray Mold Botrytis cinerea: The Role of Calcipressin in Modulating Calcineurin Activity
por: Harren, Karin, et al.
Publicado: (2012)

The role of VEGF-A(165)b in trophoblast survival
por: Bills, Victoria L, et al.
Publicado: (2014)

Sodium hyaluronate as a drug-release system for VEGF 165 improves graft revascularization in anterior cruciate ligament reconstruction in a rabbit model
por: CHEN, JIARONG, et al.
Publicado: (2012)

VEGF, VEGF165b and EG-VEGF expression is specifically related with hormone profile in pituitary adenomas
por: Corlan, Ana Silvia, et al.
Publicado: (2019)

Inhibition of retinal neovascularization by siRNA targeting VEGF(165)
por: Xia, Xiao-bo, et al.
Publicado: (2008)

Levels of vascular endothelial growth factor-A(165b) (VEGF-A(165b)) are elevated in experimental glaucoma
por: Ergorul, Ceren, et al.
Publicado: (2008)

Synthetic microparticles conjugated with VEGF(165) improve the survival of endothelial progenitor cells via microRNA-17 inhibition
por: Aday, Sezin, et al.
Publicado: (2017)

Effects of receptor tyrosine kinase inhibitors on VEGF(165)a- and VEGF(165)b-stimulated gene transcription in HEK-293 cells expressing human VEGFR2
por: Carter, Joanne J, et al.
Publicado: (2015)

Probing High Affinity Sequences of DNA Aptamer against VEGF(165)
por: Kaur, Harleen, et al.
Publicado: (2012)

Designing and Development of a Tandem Bivalent Nanobody against VEGF(165)
por: Khodabakhsh, Farnaz, et al.
Publicado: (2021)

Overexpression of VEGF(121), but not VEGF(165) or FGF-1, improves oxygenation in MCF-7 breast tumours
por: Fenton, B M, et al.
Publicado: (2004)

Development of a Multiplex Sandwich Aptamer Microarray for the Detection of VEGF(165) and Thrombin
por: Sosic, Alice, et al.
Publicado: (2013)

A pharmacokinetic binding model for bevacizumab and VEGF(165) in colorectal cancer patients
por: Panoilia, Eirini, et al.
Publicado: (2015)

Intraocular Penetration of a vNAR: In Vivo and In Vitro VEGF(165) Neutralization
por: Camacho-Villegas, Tanya A., et al.
Publicado: (2018)

The Ionophoric Activity of a Pro-Apoptotic VEGF165 Fragment on HUVEC Cells
por: Zimbone, Stefania, et al.
Publicado: (2020)

Heparin-Induced Changes of Vascular Endothelial Growth Factor (VEGF(165)) Structure
por: Nemashkalova, Ekaterina L., et al.
Publicado: (2023)

Computational drug repositioning for peripheral arterial disease: prediction of anti-inflammatory and pro-angiogenic therapeutics
por: Chu, Liang-Hui, et al.
Publicado: (2015)

Low-potential immunosensor-based detection of the vascular growth factor 165 (VEGF(165)) using the nanocomposite platform of cobalt metal–organic framework
por: Singh, Sima, et al.
Publicado: (2020)

Regulation of human feto-placental endothelial barrier integrity by vascular endothelial growth factors: competitive interplay between VEGF-A(165)a, VEGF-A(165)b, PIGF and VE-cadherin
por: Pang, Vincent, et al.
Publicado: (2017)

VEGF-A165 is the predominant VEGF-A isoform in platelets, while VEGF-A121 is abundant in serum and plasma from healthy individuals
por: Yamakuchi, Munekazu, et al.
Publicado: (2023)

Anti-angiogenic alternatives to VEGF blockade
por: Khan, Kabir A., et al.
Publicado: (2015)

Secretion of VEGF-165 has unique characteristics, including shedding from the plasma membrane
por: Guzmán-Hernández, Maria Luisa, et al.
Publicado: (2014)

VEGF 165 Gene Therapy for Patients with Refractory Angina: Mobilization of Endothelial Progenitor Cells
por: Rodrigues, Clarissa G., et al.
Publicado: (2013)

Results of an International Postmarketing Surveillance Study of pl-VEGF165 Safety and Efficacy in 210 Patients with Peripheral Arterial Disease
por: Deev, Roman, et al.
Publicado: (2017)

Enhanced angiogenesis in ischemic skeletal muscle after transplantation of cell sheets from baculovirus-transduced adipose-derived stromal cells expressing VEGF165
por: Makarevich, Pavel I., et al.
Publicado: (2015)

Therapeutic Angiogenesis by a “Dynamic Duo”: Simultaneous Expression of HGF and VEGF165 by Novel Bicistronic Plasmid Restores Blood Flow in Ischemic Skeletal Muscle
por: Slobodkina, Ekaterina, et al.
Publicado: (2020)

Clinical improvement after treatment with VEGF(165) in patients with severe chronic lower limb ischaemia
por: Anghel, Andrei, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_lia2114veq0q66l0oie1528d8a