Tumor cell p38 inhibition to overcome immunotherapy resistance

Patients with tumors that do not respond to immune-checkpoint inhibition often harbor a non-T cell-inflamed tumor microenvironment, characterized by the absence of IFN-γ-associated CD8(+) T cell and dendritic cell activation. Understanding the molecular mechanisms underlying immune exclusion in non-...

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Detalles Bibliográficos
Autores principales: Luke, Jason J., Dadey, Rebekah E., Augustin, Ryan C., Newman, Sarah, Singh, Krishna B., Doerfler, Rose, Behr, Sarah, Lee, Patrice, Isett, Brian, Deitrick, Christopher, Li, Aofei, Joy, Marion, Reeder, Carly, Smith, Katelyn, Urban, Julie, Sellitto, Lorenzo, Jelinek, Mark, Christner, Susan M., Beumer, Jan H., Villaruz, Liza C., Kulkarni, Aditi, Davar, Diwakar, Poklepovic, Andrew S., Najjar, Yana, Zandberg, Dan P., Soloff, Adam C., Bruno, Tullia C., Vujanović, Lazar, Skinner, Heath D., Ferris, Robert L., Bao, Riyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462255/
https://www.ncbi.nlm.nih.gov/pubmed/37645831
http://dx.doi.org/10.21203/rs.3.rs-3183496/v1

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