Preventing mitochondrial reverse electron transport as a strategy for cardioprotection

In the context of myocardial infarction, the burst of superoxide generated by reverse electron transport (RET) at complex I in mitochondria is a crucial trigger for damage during ischaemia/reperfusion (I/R) injury. Here we outline the necessary conditions for superoxide production by RET at complex...

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Detalles Bibliográficos
Autores principales: Prag, Hiran A., Murphy, Michael P., Krieg, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Mitochondria at the Heart of Cardioprotection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462584/
https://www.ncbi.nlm.nih.gov/pubmed/37639068
http://dx.doi.org/10.1007/s00395-023-01002-4
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author Prag, Hiran A.
Murphy, Michael P.
Krieg, Thomas
author_facet Prag, Hiran A.
Murphy, Michael P.
Krieg, Thomas
author_sort Prag, Hiran A.
collection PubMed
description In the context of myocardial infarction, the burst of superoxide generated by reverse electron transport (RET) at complex I in mitochondria is a crucial trigger for damage during ischaemia/reperfusion (I/R) injury. Here we outline the necessary conditions for superoxide production by RET at complex I and how it can occur during reperfusion. In addition, we explore various pathways that are implicated in generating the conditions for RET to occur and suggest potential therapeutic strategies to target RET, aiming to achieve cardioprotection.
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spelling pubmed-104625842023-08-30 Preventing mitochondrial reverse electron transport as a strategy for cardioprotection Prag, Hiran A. Murphy, Michael P. Krieg, Thomas Basic Res Cardiol Mitochondria at the Heart of Cardioprotection In the context of myocardial infarction, the burst of superoxide generated by reverse electron transport (RET) at complex I in mitochondria is a crucial trigger for damage during ischaemia/reperfusion (I/R) injury. Here we outline the necessary conditions for superoxide production by RET at complex I and how it can occur during reperfusion. In addition, we explore various pathways that are implicated in generating the conditions for RET to occur and suggest potential therapeutic strategies to target RET, aiming to achieve cardioprotection. Springer Berlin Heidelberg 2023-08-28 2023 /pmc/articles/PMC10462584/ /pubmed/37639068 http://dx.doi.org/10.1007/s00395-023-01002-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mitochondria at the Heart of Cardioprotection
Prag, Hiran A.
Murphy, Michael P.
Krieg, Thomas
Preventing mitochondrial reverse electron transport as a strategy for cardioprotection
title Preventing mitochondrial reverse electron transport as a strategy for cardioprotection
title_full Preventing mitochondrial reverse electron transport as a strategy for cardioprotection
title_fullStr Preventing mitochondrial reverse electron transport as a strategy for cardioprotection
title_full_unstemmed Preventing mitochondrial reverse electron transport as a strategy for cardioprotection
title_short Preventing mitochondrial reverse electron transport as a strategy for cardioprotection
title_sort preventing mitochondrial reverse electron transport as a strategy for cardioprotection
topic Mitochondria at the Heart of Cardioprotection
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462584/
https://www.ncbi.nlm.nih.gov/pubmed/37639068
http://dx.doi.org/10.1007/s00395-023-01002-4
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