DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability

Molecular chaperone HSP70s are attractive targets for cancer therapy, but their substrate broadness and functional non-specificity have limited their role in therapeutical success. Functioning as HSP70’s cochaperones, HSP40s determine the client specificity of HSP70s, and could be better targets for...

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Detalles Bibliográficos
Autores principales: Huang, Yaping, Lu, Changzheng, Wang, Hanzhi, Gu, Liya, Fu, Yang-Xin, Li, Guo-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462666/
https://www.ncbi.nlm.nih.gov/pubmed/37640708
http://dx.doi.org/10.1038/s41467-023-40952-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462666/
https://www.ncbi.nlm.nih.gov/pubmed/37640708
http://dx.doi.org/10.1038/s41467-023-40952-0

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