The yeast guanine nucleotide exchange factor Sec7 is a bottleneck in spatial protein quality control and detoxifies neurological disease proteins

ER-to-Golgi trafficking partakes in the sorting of misfolded cytoplasmic proteins to reduce their cytological toxicity. We show here that yeast Sec7, a protein involved in proliferation of the Golgi, is part of this pathway and participates in an Hsp70-dependent formation of insoluble protein deposi...

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Detalles Bibliográficos
Autores principales: Babazadeh, Roja, Schneider, Kara L., Fischbach, Arthur, Hao, Xinxin, Liu, Beidong, Nystrom, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462735/
https://www.ncbi.nlm.nih.gov/pubmed/37640758
http://dx.doi.org/10.1038/s41598-023-41188-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462735/
https://www.ncbi.nlm.nih.gov/pubmed/37640758
http://dx.doi.org/10.1038/s41598-023-41188-0

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