Improved tropoelastin synthesis in the skin by codon optimization and nucleotide modification of tropoelastin-encoding synthetic mRNA

Loss of elastin due to aging, disease, or injury can lead to impaired tissue function. In this study, de novo tropoelastin (TE) synthesis is investigated in vitro and in vivo using different TE-encoding synthetic mRNA variants after codon optimization and nucleotide modification. Codon optimization...

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Detalles Bibliográficos
Autores principales: Golombek, Sonia, Hoffmann, Thomas, Hann, Ludmilla, Mandler, Markus, Schmidhuber, Sabine, Weber, Josefin, Chang, Young-Tae, Mehling, Roman, Ladinig, Andrea, Knecht, Christian, Leyens, Johanna, Schlensak, Christian, Wendel, Hans Peter, Schneeberger, Achim, Avci-Adali, Meltem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462787/
https://www.ncbi.nlm.nih.gov/pubmed/37650117
http://dx.doi.org/10.1016/j.omtn.2023.07.035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462787/
https://www.ncbi.nlm.nih.gov/pubmed/37650117
http://dx.doi.org/10.1016/j.omtn.2023.07.035

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