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Novel pneumococcal capsule type 33E results from the inactivation of glycosyltransferase WciE in vaccine type 33F
The polysaccharide (PS) capsule is essential for immune evasion and virulence of Streptococcus pneumoniae. Existing pneumococcal vaccines are designed to elicit anticapsule antibodies; however, the effectiveness of these vaccines is being challenged by the emergence of new capsule types or variants....
Autores principales: | Ganaie, Feroze A., Saad, Jamil S., Lo, Stephanie W., McGee, Lesley, van Tonder, Andries J., Hawkins, Paulina A., Calix, Juan J., Bentley, Stephen D., Nahm, Moon H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462825/ https://www.ncbi.nlm.nih.gov/pubmed/37495106 http://dx.doi.org/10.1016/j.jbc.2023.105085 |
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